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Term: biotin
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Biotin: Mechanisms of interference in immunoassays and mitigation strategies

By Editor on 1/20/2020

By Victor Leung, Dana Nyholt-Bailey, IQMH Endocrinology and Immunology Scientific Committee and Staff

Introduction

Recent years have seen a significant increase in the number of cases of biotin interference with streptavidin-biotin (SB)-based immunoassays reported in the literature. Biotin interference with laboratory tests, specifically SB-based immunoassays, is potentially dangerous, as it may cause spurious test results leading to misdiagnosis and patient mismanagement.

 

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