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Editor

Biotin: Mechanisms of interference in immunoassays and mitigation strategies

By Editor on 1/20/2020

By Victor Leung, Dana Nyholt-Bailey, IQMH Endocrinology and Immunology Scientific Committee and Staff

Introduction

Recent years have seen a significant increase in the number of cases of biotin interference with streptavidin-biotin (SB)-based immunoassays reported in the literature. Biotin interference with laboratory tests, specifically SB-based immunoassays, is potentially dangerous, as it may cause spurious test results leading to misdiagnosis and patient mismanagement.

The U.S. Food and Drug Administration (FDA) recently reported increased adverse events related to biotin interference of SB-dependent immunoassays including a falsely low troponin and subsequent death1, whereas Health Canada has published at least nine Recalls & Safety Alerts since 2017 related to biotin interference of lab tests in commonly used clinical analyzers.2 Most commonly are those associated with inaccurate thyroid hormone or PTH quantitation; most significantly are those associated with deaths including false-negative troponin. Less commonly reported are interferences impacting pregnancy testing or infectious disease serology. These public reports clearly demonstrate an urgent need to address the issues pertaining to biotin interference.

What is biotin?

IQMH
biotin
Centre for Proficiency Testing
endocrinology
Immunology

Server Shutdown - QView™ and IQMH.org will not be available

By Editor on 1/7/2020

QView.ca and IQMH.org will not be available on Saturday, January 25th starting at 9:00 p.m. (ET) until 9:00 a.m. (ET) due to planned maintenance. You are encouraged to make appropriate work-related arrangements to accommodate the server shutdown.

IQMH
iqmh

A New Outlook on Internal Auditing in London, Ontario

By Editor on 1/6/2020


Thursday, April 30 to Friday, May 1, 2020

Centre for Education
Centre for Education
in-class courses
London

President's End of Year Message

By Editor on 12/19/2019

There are times it feels difficult to believe that the holiday season is almost upon us once again. This year seems to have gone by especially quickly! I guess the old adage about time appearing to pass by faster and faster the older you get is true—at least for me!  In any case, here we are, and I’d like to take this opportunity to wish you peace, hope and joy during the holiday season, and throughout 2020.

IQMH
iqmh
Message from the President

Version 8 of the IQMH Medical Laboratory Accreditation Requirements is now available!

By Editor on 12/18/2019
We are pleased to announce that Version 8 (December 2019) of the IQMH Medical Laboratory Accreditation Requirements is now available. Laboratories currently enrolled for IQMH Accreditation have access to all files related to this version via their password-protected QView™ account. The QView™ folder with these files can be found under “General - Accreditation, Laboratory Program, Accreditation Requirements”. It contains the requirements, a change report comparing Version 7.1 to Version 8, and an updated list of references to support the requirements. Documents are available in English and in French.
accreditation requirements
Centre for Accreditation
IQMH Medical Laboratory Accreditation Requirements
ISO 15189 Plus medical laboratory accreditation

Congratulations to our newest ISO 15189 Plus™-accredited facility

By Editor on 12/16/2019


We are pleased to announce that William Osler Health System has achieved ISO 15189 Plus™ Accreditation for the services they provide on the floor they operate at the Reactivation Care Centre (RCC), Church St. Site.

accredited facilities
Centre for Accreditation
ISO 15189 Plus medical laboratory accreditation

Order Deadline for Proficiency Testing surveys is fast approaching. Act now!

By Editor on 11/29/2019

Order deadline December 15, 2019


The IQMH Centre for Proficiency Testing is pleased to announce the availability of its Proficiency Testing Programs in the 2020 Catalogue.

2020 PT Testing Program
Centre for Proficiency Testing
PT surveys

Important Changes to IQMH Chemistry and Endocrinology Proficiency Testing Surveys in 2020

By Editor on 11/29/2019

Attention: Chemistry and Endocrinology Proficiency Testing (PT) Participants

2020 PT Testing Program
Centre for Proficiency Testing
Chemistry
endocrinology
proficiency testing programs

 

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